| To evaluate the effects of sodium cyclamate on the rat placenta by its administration in the period of embryogenesis. The sodium cyclamate was administered by intraperitoneal route in rats of the treated group at the dose of 60 mg/Kg, from the tenth to fourteenth day of gestation, while the equivalent volume of saline solution was given to the control group, by the same route. On the twentieth day of pregnancy, 10 fetuses (5 from each group) were chosen at random for study. The technique of cariometry was utilized for evaluation of nuclear parameters of cells in deciduous and spongy layers, and of chorionic villi in the rat placenta. The weights of treated fetuses and their placentas were less than those of the control group, while umbilical-cord length in... |
